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Brands Fitness – HMB-FA supplementation increased skeletal muscle

The present study showed that HMB enhances the positive effects of resistance training on strength
The present study showed that HMB enhances the positive effects of resistance training on strength

BRANDS FITNESS – RESEARCH ARTICLE

Eccentric resistance training and β-hydroxy-β-methylbutyrate free acid affects muscle PGC-1α expression and serum irisin, nesfatin-1 and resistin in rats

Hossein Shirvani, Saleh Rahmati-Ahmadabad, David Robert Broom, Reza Mirnejad
Journal of Experimental Biology 2019 222: jeb198424 doi: 10.1242/jeb.198424 Published 29 May 2019

ABSTRACT

The hypothalamus controls metabolism and feeding behaviour via several signals with other tissues. Exercise and supplements can change hypothalamic signalling pathways, so the present study investigated the influence of eccentric resistance training and β-hydroxy-β-methylbutyrate free acid supplementation on PGC-1α expression, serum irisin, nesfatin-1 and resistin concentrations. 

INTRODUCTION

In the last decade, the use of supplements such as β-hydroxy-β-methylbutyrate (HMB) to promote fat loss and muscle growth has increased. HMB is an active metabolite of the nutritionally essential branched-chain amino acid (BCAA) leucine, which has an anticatabolic role for muscle (reduces breakdown of muscle cell proteins). Evidence suggests that the inhibitory effects of HMB on the dexamethasone-induced increase in protein degradation and decrease in protein synthesis are regulated by p38/MAPK- and PI3K/Akt-dependent cell signalling, respectively.

MATERIALS AND METHODS

Permissions

The present study was conducted with the written permission of the research deputy of Baqiyatallah University (ethical code: IR.BMSU.REC.1394.82) and was in accordance with National Institutes of Health (NIH) guidelines.

DISCUSSION

The present study showed that HMB enhances the positive effects of resistance training on strength .

CONCLUSIONS

The most important findings of the present study are that a combination of eccentric resistance training and HMB-FA supplementation has a greater effect on the primary outcome compared with exercise or supplement intervention alone. Exercise and HMB-FA supplementation could increase PGC-1α gene expression, which may regulate other peptide-releasing tissues and change serum concentrations of irisin, nesfatin-1 and resistin. We found that HMB-FA supplementation with eccentric resistance training may induce crosstalk between releasing peptides from other tissues and increases maximal muscle strength.

Acknowledgements

The authors appreciate the helpful comments of A. Ghanbari-Niaki (Exercise Biochemistry Division, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran).

FOOTNOTES

  • Competing interestsThe authors declare no competing or financial interests.
  • Author contributionsConceptualization: H.S., S.R.; Methodology: H.S., S.R.; Software: H.S., S.R., R.M.; Validation: S.R., D.R.B.; Formal analysis: S.R., D.R.B., R.M.; Investigation: H.S., S.R., D.R.B.; Resources: S.R.; Data curation: S.R., R.M.; Writing – original draft: H.S., S.R.; Writing – review & editing: S.R., D.R.B., R.M.; Visualization: S.R.; Supervision: S.R.; Project administration: H.S.; Funding acquisition: H.S., R.M.
  • FundingThis research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.
  • Received December 17, 2018.
  • Accepted May 5, 2019.
  • © 2019. Published by The Company of Biologists Ltd
Busy Researcher Typing Scientific Article
Busy Researcher Typing Scientific Article