Brands Fitness | Supplements | Amino Acids | L-Glutamine
Brands Fitness | Supplements | Amino Acids | L-Glutamine
- Amino Acids
- Pure Powder
- Nitrogen Transporter
- Immune Support
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Glutamine is considered to be a conditionally essential amino acid, which means that under certain circumstances, the body may require more glutamine than it can produce. In the body, glutamine functions as a major nitrogen transporter and is critical for the maintenance of healthy nitrogen balance. Glutamine also acts as the primary fuel for the rapidly growing cells of the immune system and GI tract.
Mix 1 rounded teaspoon in juice, preferably between meals, 1 to 2 times daily as needed.
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
NOW L-Glutamine Powder is a pure, free-form, non-essential amino acid and is the highest grade available.
Caution: For adults only. Consult physician if pregnant/nursing, taking medication, or have a medical condition (including liver disease, bipolar disorder). Keep out of reach of children.
Do not eat freshness packet enclosed.
Natural color variation may occur in this product.
This product is sold by weight not volume.
Store in a cool, dry, dark place after opening.
Did you know that when you exercise you’re not just stressing your muscles?
Physical exertion sets off a cascade of stress responses in the body that, if left unaddressed, can make it harder for you to recover and harder for you to achieve the gains you’re working toward.
Got your attention? Good. Because L-Glutamine not only can help to address the many different stressors that arise from physical exertion, but can also help you in a variety of other ways.
Check out these L-Glutamine benefits:
- Helps to maintain a positive nitrogen balance, referred to as an anabolic state, which is crucial for any active individual.*
- Aids in the production of rapidly growing cells, such as immune system lymphocytes and intestinal cell enterocytes, which can help to off-set some of the stress from physical exertion.*
- Helps to regulate the body’s acid-alkaline balance (also known as body pH); homeostasis is critical for overall fitness.*
Glutamine is considered a “conditionally essential” amino acid, meaning that when your body is under an inordinate amount of stress, such as during strenuous exercise, it needs more glutamine than it can normally produce internally.
Specifically, it needs a NOW® Sports Glutamine supplement because our L-Glutamine products are carefully screened for purity and potency and are manufactured according to our industry-leading quality assurance standards. And we always use the natural “L” form amino acids, because we believe that natural is better.
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Scientific Article on Glutamine
At the most basic level, amino acids are the building blocks of proteins in our cells and tissues, and after water are the second most abundant compound in mammals. Amino acids can be obtained from endogenous and/or exogenous (i.e., diet) proteins, and their availability is of fundamental importance for cell survival, maintenance, and proliferation. Mammals, in particular, have developed biochemical and metabolic pathways to control pathogen infection by increasing amino acid catabolism to aid immune responses, thus restricting the availability of nitrogen-containing nutrients to invading microorganisms. This evolutionary mechanism also becomes advantageous for the host to control its own inflammatory responses to infections.
Among the 20 amino acids detailed in the genetic code, glutamine provides the best example of the versatility of amino acid metabolism and immune function. Glutamine is the most abundant and versatile amino acid in the body, and is of fundamental importance to intermediary metabolism, interorgan nitrogen exchange via ammonia (NH3) transport between tissues, and pH homeostasis. In almost every cell, glutamine can be used as a substrate for nucleotide synthesis (purines, pyrimidines, and amino sugars), nicotinamide adenine dinucleotide phosphate (NADPH), antioxidants, and many other biosynthetic pathways involved in the maintenance of cellular integrity and function.
Most cells in the body function with a constant turnover and/or supply of nutrients, however, cells of the immune system frequently have to function under nutrient restricted microenvironments. Although glucose is a vital metabolite, and the main fuel for a large number of cells in the body, cells of the immune system, such as lymphocytes, neutrophils, and macrophages, utilize glutamine at high rates similar to or greater than glucose under catabolic conditions, such as sepsis, recovery from burns or surgery, and malnutrition, as well as high intensity/volume physical exercise. This theory was first experimentally confirmed in the 1980’s by the laboratory of Eric Newsholme (1935–2011, widely accepted now as the origin of hypotheses and evidence for the concept of “immunometabolism”) in the University of Oxford, and subsequently by many other laboratories worldwide. For this reason, glutamine is considered as a “fuel for the immune system”, where a low blood concentration may impair immune cell function, resulting in poor clinical outcomes and increased risk of mortality.
Currently, glutamine is routinely supplied as a component of clinical nutrition supplementation for pre-and post-operative patients, and also for many elite athletes to restore immune functions. Although there is a growing evidence in support of the immune mediating effects of glutamine supplementation, several questions and specific considerations still remain. Therefore, the aim of the present study is to provide an integrated review on how glutamine metabolism in key organs, such as the gut, liver, and skeletal muscles, is important to cells of the immune system. These key organs control glutamine availability and shed light on important considerations in regards to glutaminemia (glutamine concentration into the bloodstream). The immune-enhancing properties and related paradigms of glutamine supplementation in health and disease are also discussed herein.
Read the full article
Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation
by Vinicius Cruzat 1,2,OrcID,Marcelo Macedo Rogero 3OrcID,Kevin Noel Keane 1,Rui Curi 4 andPhilip Newsholme 1,
Nutrients 2018, 10 (11), 1564; https://doi.org/10.3390/nu10111564
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