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Gamma-Oryzanol is a naturally occurring plant sterol derived from rice bran oil. It has long been popular among athletes.
Men – 1 to 3 tablets; Women – 1 tablet. Take once daily, preferably on an empty stomach (3 or more hours after a meal) and 45 minutes prior to a workout. May also be taken at night before retiring.
Dibasic calcium phosphate, microcrystalline cellulose, stearic acid, modified cellulose gum, and magnesium stearate.
Suitable for vegetarians and Hypoallergenic: Contains no yeast, dairy, egg, gluten, corn, soy or wheat. Contains no sugar, starch, salt, preservatives or artificial color, flavor or fragrance.
Note: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.
Do not use if either tamper-evident seal is broken or missing. Keep out of the reach of children.
What other names is Gamma Oryzanol known by?
Gama Orizanol, Gamma-Oryzanol, Gamma-OZ, Oryzanol.
What is Gamma Oryzanol?
Gamma oryzanol is a substance that is taken out of rice bran oil. It is also found in wheat bran and some fruits and vegetables. People use it as medicine.
Gamma oryzanol is used for high cholesterol and symptoms of menopause and aging.
Some people use it for increasing testosterone and human growth hormone levels, as well as improving strength during resistance exercise training.
γ-Oryzanol suppresses cell apoptosis by inhibiting reactive oxygen species-mediated mitochondrial signaling pathway in H2O2-stimulated L02 cells
γ-Oryzanol, a mixture of ferulic acid esters of plant sterols and triterpene alcohols existed in rice bran oil, can ameliorate lipid metabolism and enhance antioxidant activity.
Rice is one of the main components of human diet. γ-Oryzanol, a bioactive compound existed in rice bran oil (RBO), is a mixture of phytosteryl and triterpenyl esters of ferulic acid. Microflora in the human gut can hydrolyze these compounds, releasing ferulic acid for absorption or degradation. γ-Oryzanol has been shown to inhibit tumor growth, reduce cholesterol levels and glucose intolerance, protect against development of gastric ulcers, and enhance the activity of antioxidant. It was demonstrated that ferulic acid, the main metabolite of γ-oryzanol, had higher antioxidant activity than vitamin E, and the content of γ-oryzanol was 10 times more than vitamin E in rice bran. Therefore, γ-oryzanol may be a more important antioxidant substance in rice bran than vitamin E.
Rice, one of the staple foods of human diet worldwide, contains numerous bioactive nutrients, and is important in maintaining a healthy lifestyle. The bioactive phytochemicals in rice include phenolics, anthocyanins, flavones, vitamin E, and γ-oryzanol; γ-oryzanol shows anti-hyperlipidemic, anti-inflammatory, and antioxidant activity.
In summary, pre-treatment with γ-oryzanol protected L02 cells from oxidative stress induced by exposure to H2O2. Pre-treatment with γ-oryzanol significantly elevated the activity of intracellular antioxidases, inhibited ROS accumulation, and suppressed H2O2-induced apoptosis by restoring MMP. Pre-treatment with γ-oryzanol also regulated the expression of Bcl-2 and Bax, and inhibited activation of caspases-9 and -3. These findings indicate that γ-oryzanol exerts antioxidative and antiapoptotic effects by suppressing intracellular ROS accumulation and impeding ROS-activated mitochondria-mediated apoptosis in L02 cells exposed to H2O2.
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Author LinHuang, WeiweiJiang, LijuanZhu, ChaoyangMa, ZhaopingOu, ChenxiLuo, JingWu, LixinWen, ZhuliangTan, JineYi
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