Brands Fitness | Supplements | Amino Acids | L-Arginine
- Double Strength
- Amino Acid
- Conditionally Essential Amino Acid
- Nitric Oxide Precursor
- A Dietary Supplement
- Amino Acids
- Family Owned Since 1968
- GMP Quality Assured
L-Arginine is conditionally essential basic amino acid involved primarily in urea metabolism and excretion, as well as in DNA synthesis and protein production. It is an important precursor of Nitric Oxide (NO) and thus plays a role in the dilation of blood vessels.
The L-Arginine used in this product is Pharmaceutical Grade.
Take 1 tablet twice daily as needed. Take between meals or at bedtime with a carbohydrate drink to facilitate absorption.
Cellulose, stearic acid (vegetable source), croscarmellose sodium, silica and vegetarian coating.
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
This product has twice the L-Arginine (1,000 mg per tablet) as in our regular strength product (500 mg per capsule).
Store in a cool, dry place after opening.
Caution: For adults only. Consult physician if pregnant/nursing, taking medication, or have a medical condition. This supplement should be avoided by persons with glaucoma or herpes simplex unless otherwise prescribed by a physician. Do not use if you have a myocardial infection or have established coronary artery disease. Keep out of reach of children.
Do not eat freshness packet. Keep in bottle.
Natural color variation may occur in this product.
If you’re into fitness and exercise then you’re most likely familiar with amino acids in general.
But with 20 different amino acids to typically choose from at your local gym or health food store, as well as a huge number of variations and combinations, you may be wondering which ones to add to your supplementation regimen.
Many active individuals choose to supplement with the amino acid L-Arginine. Here are a few L-Arginine benefits:
- Arginine is a precursor to nitric oxide (NO), a molecule that helps to open up blood vessels, which increases the flow of blood to muscular tissues.*
- Because nitric oxide is an important component of the endothelium, which is the layer of cells that lines the interior of our blood vessels, Arginine may help to support healthy circulatory function.*
- Arginine plays an essential role in the maintenance of proper nitrogen balance through its participation in the metabolism ammonia and excretion of urea.*
- Arginine supports normal liver detoxification processes, helping your body eliminate toxic materials and supporting overall metabolic health.*
- This important amino acid also supports healthy immune system function.*
L-Arginine is classified as a “conditionally essential” amino acid. In certain stressful situations, such as illness or injury, the body requires higher levels of these amino acids from the diet.
Since exercise is basically controlled injury of your muscle tissue, you can see how an L-Arginine supplement can benefit exercise recovery.*
NOW® Sports L-Arginine products are carefully screened for purity and potency and are manufactured with our industry-leading quality assurance procedures. And we always use the natural “L” form amino acids, because we believe that natural is better.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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Scientific Article fitness
L-arginine, a semi-essential amino acid, is well known as a precursor for bioactive substance syntheses, such as nitric oxide (NO), growth hormone and creatine. L-arginine is essential for maintaining adequate immune function by improving cell proliferation, increasing antioxidant defenses and enhancing cell protective mechanisms. Across different species, including rodents, pigs and humans, diets with low concentrations of L-arginine lead to decreased circulating levels of this amino acid.
Since L-arginine demonstrates notable antioxidant properties, such as being a scavenger of reactive oxygen species (ROS) mainly by reducing superoxide and hydroxyl radical oxidative damage, a deficient intake of L-arginine may be detrimental to the redox homeostasis of several organs. When the excessive production of ROS overcomes cellular antioxidant capacity, some cellular lesions may occur on different biomolecules; these can be identified, and include lipid peroxidation, protein carbonylation, and DNA strand breaks. DNA damage plays an important role in mutagenesis, carcinogenesis and aging; the accumulation of DNA lesions by ROS has therefore been demonstrated to be a significant risk factor for the development of cardiovascular diseases and cancer. These lesions also alter immune function by impairing of cell proliferation and phagocytosis activity.
High-intensity or long-term strenuous exercises represents a stress situation that promotes a decrease in indispensable amino acid concentrations; this scenario is accompanied by a release into plasma of substances indicative of muscle damage, mainly due to the production of ROS. The use of L-arginine supplements in animal models of exhaustive exercise training has shown increases in antioxidant defense in liver and muscles, and these effects were accompanied by cytoprotective expressions of 70 kDa heat shock proteins (HSP70) in both cell cytoplasm and nuclei . Exercise-induced HSP70 expression in immune cells, and the release of these proteins from immune cells to the blood (in the extracellular milieu named as e, has also been found to be related to oxidative stress and inflammation in immune cells.
L-arginine also increases blood flow by endothelium vasodilatation mediated by NO. Similarly, there is evidence that resistance training induces benefits in vascular function mediated by NO modulation and antioxidant effects. These benefits to vascular function can also improve cardiac function using both L-arginine supplementation and resistance training.
This rationale reinforces the hypothesis that L-arginine supplementation provides increased nutrient support to skeletal muscles and can also improve the removal of metabolites after exercise, making it a promising ergogenic supplement in strength training. Although the parallel benefits of resistance exercise and L-arginine supplementation have been previously studied in terms of their immune system, cardiovascular system and oxidative profiles, the association between resistance training and L-arginine supplementation on these parameters has not yet been investigated. For this study, we hypothesized that resistance exercise and L-arginine supplementation have a synergistic effect on hemodynamic, oxidative, biochemical and biometric improvements.
PLoS One. 2018; 13(9): e0204858.Published online 2018 Sep 27. doi: 10.1371/journal.pone.0204858
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